MyGI Diet for Colorectal Cancer Prevention
The MyBestGI study evaluates three different approaches that could help people eat in healthier ways. The study seeks to enroll 240 overweight and obese persons who have risk factors for colorectal cancers such as a family or personal history of colorectal cancers or adenomatous polyps. The study website is www.MyBestGI.org . Participants in the study will be asked to follow one of three eating plans, as best they can, for 12 months. Study participants can choose the foods they prefer within healthy food groups. Two of the eating plans involve ten brief telephone support calls and use of a web-based app (MyBestGI App). The study primarily evaluates improvements in eating and any weight change that may result. Secondary goals for the research are to evaluate how changes in eating affect metabolic pathways. All study participants will receive written materials that encourage making room for preventive foods in your daily eating. All participants also receive the results of their own diet analyses, and results of their own measures at study visits. The measures are the Veggie Meter skin reflectance test, Ketoscan breath test, and body composition measures. Study visits also involve providing a small blood sample from the arm. Study visits are in Ann Arbor at the start of the study, and at 6 and 12 months. The long-term goal of this research is to provide better options for supporting individuals who seek to achieve and maintain a preventive style of eating.
• Persons ages 19 and older
• The subject has been properly informed of the study, they agree to participate, and sign the Informed Consent document(s)
• Measured body mass index of 25-45 kg/m2 at the study eligibility visit months OR waist circumference \> 88 cm for women or \> 102 cm for men.
• Reasonably stable weight in the last two months
• Increased risk of colorectal cancer as defined by: Prior adenomatous polyp or serrated polyp OR prior resected early stage CRC (Stage I-IIIA or T1-3, N0-1, M0) OR a history of CRC in at least one primary relative or in at least two secondary relatives OR a polyp was found with a recommended follow-up colonoscopy in less than 8 years OR A known genetic condition that increases risk of CRC
• Good general health
• Have reasonable control over their own dietary intakes
• Not expecting major lifestyle changes in the next 12 months.
• Not expecting a change in hormonal therapies over the next 12 months
• Have and use a smartphone with web access
• Can be contacted by telephone for support calls
• Read and speak English
• Are able to follow a diet high in fiber-containing foods
• Agree to be randomized to a control condition of usual care versus a dietary intervention involving app use and telephone contacts
• Successfully complete three 24-hour dietary recalls online prior to baseline with plausible dietary intakes
• If taking medications for conditions that are affected by diet (diabetes, high blood pressure) must be willing to continue to follow-up with their personal medical provider as needed to manage those conditions and the medication dosing, which may need to be adjusted due to diet changes.
• Has been properly informed of the study and signed the Informed Consent document